Last year I found myself in the Sistine Chapel in Rome, glancing up at the ceiling that Michelangelo had painted more than 500 years ago. My tour guide, to my amazement pointed out that in one of the panels, The Creation of Adam, Michelangelo had drawn God and the surrounding angels in the shape and form of the human brain. This was an act that would have seen Michelangelo be executed had the Pope, or anyone else for that matter, identified the hidden symbolism in Michelangelo’s work.

For the last 10 years I have been obsessed with the Greats of history, people that have made a significant impact, some changing the course of history forever. In Michelangelo’s story, which I explore further in this week’s Manifesto, we find the timeless and repeatable ingredient in all those who have made a difference to the planet: rebellion.